Overview

Human diseases and epidemics represent a high-yield topic across both UPSC Prelims and Mains. While the Health, Nutrition & Disease chapter (Chapter 2) covers public health policy and government schemes, this chapter provides a detailed scientific classification of diseases — bacterial, viral, protozoan, and non-communicable — with pathogen-transmission-symptom tables essential for Prelims. It also covers vaccine technology, India's immunisation programme, disease eradication milestones, and major epidemics and pandemics.

Exam Strategy: Prelims frequently tests pathogen-disease-vector matching, vaccine types, and disease eradication facts. Mains (GS3 — Science & Technology; GS2 — Health) asks about pandemic preparedness, disease elimination programmes, and the intersection of science with public health policy.


Classification of Diseases

BasisTypes
By CommunicabilityCommunicable (infectious) and Non-communicable
By PathogenBacterial, Viral, Fungal, Protozoan, Helminthic
By TransmissionAirborne, Waterborne, Vector-borne, Sexually transmitted, Contact
By DurationAcute (short-term) and Chronic (long-term)

Part I — Bacterial Diseases

Major Bacterial Diseases

DiseaseCausative BacteriumTransmissionKey SymptomsTreatment
Tuberculosis (TB)Mycobacterium tuberculosisAirborne (droplet nuclei)Persistent cough (2+ weeks), blood in sputum, weight loss, night sweats, feverDOTS therapy (Directly Observed Treatment, Short-course); first-line drugs: isoniazid, rifampicin, pyrazinamide, ethambutol
CholeraVibrio choleraeWaterborne (contaminated water/food) — faecal-oral routeProfuse watery diarrhoea ("rice-water stool"), severe dehydration, vomitingOral Rehydration Solution (ORS); antibiotics (doxycycline, azithromycin) in severe cases
TyphoidSalmonella typhiWaterborne — faecal-oral route (contaminated food/water)Step-ladder fever (rising day by day), headache, abdominal pain, rose spots on abdomenAntibiotics (ciprofloxacin, azithromycin); Widal test for diagnosis
PlagueYersinia pestisVector-borne (rat flea — Xenopsylla cheopis); also airborne (pneumonic plague)Bubonic: swollen lymph nodes (buboes); Pneumonic: severe pneumonia; Septicaemic: bloodstream infectionAntibiotics (streptomycin, gentamicin); historically caused pandemics — the Black Death (1346-53) killed ~30-60% of Europe's population
Leprosy (Hansen's Disease)Mycobacterium lepraeProlonged close contact; droplet infection from noseSkin lesions, nerve damage, loss of sensation in extremities, deformities if untreatedMulti-drug therapy (MDT): dapsone, rifampicin, clofazimine; India eliminated leprosy as a public health problem in 2005 (prevalence <1 per 10,000)
DiphtheriaCorynebacterium diphtheriaeAirborne (respiratory droplets)Sore throat, greyish-white membrane in throat, fever, swollen neck glandsAntitoxin + antibiotics; DPT vaccine (preventable)
TetanusClostridium tetaniWound infection (spores enter through cuts)Muscle spasms (lockjaw), stiffness, difficulty swallowingTetanus immunoglobulin + antibiotics; TT vaccine (preventable)
Pertussis (Whooping Cough)Bordetella pertussisAirborne (respiratory droplets)Severe coughing fits with a "whoop" sound, vomiting after coughAntibiotics (erythromycin); DPT vaccine (preventable)

Prelims Tip: TB, Diphtheria, Pertussis, and Tetanus are all covered under India's Universal Immunisation Programme. The BCG vaccine protects against TB; the DPT vaccine covers Diphtheria, Pertussis, and Tetanus.


Part II — Viral Diseases

Major Viral Diseases

DiseaseVirusTransmissionKey SymptomsVaccine Available?
HIV/AIDSHuman Immunodeficiency Virus (HIV-1, HIV-2)Sexual contact, blood transfusion, mother-to-child, contaminated needlesProgressive destruction of immune system (CD4+ T cells); opportunistic infectionsNo vaccine; Antiretroviral Therapy (ART) controls viral load
DengueDengue virus (4 serotypes: DENV-1 to DENV-4)Vector-borne — Aedes aegypti mosquitoHigh fever, severe headache, pain behind eyes, joint/muscle pain, rash; severe dengue: plasma leakage, organ damageDengvaxia vaccine (limited use); mainly prevention through vector control
COVID-19SARS-CoV-2 (coronavirus)Airborne (respiratory droplets and aerosols); contactFever, cough, breathlessness, loss of taste/smell; severe: pneumonia, ARDS, organ failureYes — mRNA vaccines (Pfizer-BioNTech, Moderna), viral vector (AstraZeneca/Covishield), inactivated (Covaxin)
InfluenzaInfluenza virus (Types A, B, C)Airborne (respiratory droplets)Fever, body ache, cough, fatigueAnnual flu vaccine (updated each year due to antigenic drift)
RabiesRabies virus (Lyssavirus)Animal bite (saliva of infected animal — dogs, bats, monkeys)Hydrophobia (fear of water), agitation, hallucinations; nearly 100% fatal once symptoms appearYes — post-exposure prophylaxis (PEP) with rabies vaccine is highly effective if given promptly
EbolaEbola virus (5 species; Zaire ebolavirus most lethal)Contact with infected blood, body fluids, or contaminated surfacesFever, severe headache, vomiting, diarrhoea, haemorrhage; case fatality rate up to 90%rVSV-ZEBOV vaccine (Ervebo) approved 2019
PoliomyelitisPoliovirus (3 types)Faecal-oral route (contaminated water/food)Most infections asymptomatic; 1 in 200 causes irreversible paralysisOPV (Oral Polio Vaccine — Sabin) and IPV (Injectable — Salk); India certified polio-free on 27 March 2014
MeaslesMeasles virus (Morbillivirus)Airborne (one of the most contagious diseases)Fever, cough, runny nose, Koplik spots (white spots inside mouth), red rashYes — MMR vaccine (Measles, Mumps, Rubella)

Hepatitis — Types A through E

TypeVirusTransmissionChronicityVaccine
Hepatitis AHAVFaecal-oral (contaminated food/water)No — acute onlyYes
Hepatitis BHBVBlood-borne (blood, sexual contact, mother-to-child)Yes — can become chronic; causes liver cirrhosis, cancerYes — part of UIP in India
Hepatitis CHCVBlood-borne (blood transfusion, needles, rarely sexual)Yes — often becomes chronicNo vaccine; curable with Direct-Acting Antivirals (DAAs)
Hepatitis DHDVBlood-borne — but only co-infects with Hepatitis BYes — worsens HBV prognosisHBV vaccine prevents HDV (since HDV requires HBV)
Hepatitis EHEVFaecal-oral (contaminated water)No — usually acute; dangerous in pregnant womenVaccine exists (Hecolin) but not widely available

Prelims Tip: Remember the simple rule: Hepatitis A and E are waterborne (faecal-oral); Hepatitis B, C, and D are blood-borne. Only Hepatitis B and C can become chronic. The HBV vaccine also prevents HDV.


Part III — Protozoan Diseases

Major Protozoan Diseases

DiseaseCausative OrganismTransmissionKey Symptoms
MalariaPlasmodium species (see table below)Vector-borne — female Anopheles mosquitoCyclical fever with chills, anaemia, enlarged spleen; cerebral malaria (P. falciparum) can be fatal
Kala-azar (Visceral Leishmaniasis)Leishmania donovaniVector-borne — sandfly (Phlebotomus argentipes)Prolonged fever, weight loss, enlarged spleen and liver, anaemia, darkening of skin; endemic in Bihar, Jharkhand, UP, West Bengal; elimination target: <1 case/10,000 at sub-district level
Sleeping Sickness (African Trypanosomiasis)Trypanosoma bruceiVector-borne — tsetse fly (Glossina)Fever, headache, joint pain; later stage: confusion, sleep disturbance, coma
Amoebic DysenteryEntamoeba histolyticaFaecal-oral (contaminated water/food)Bloody diarrhoea, abdominal cramps, liver abscess
GiardiasisGiardia lambliaFaecal-oral (contaminated water)Diarrhoea, bloating, nausea, malabsorption

Malaria — Plasmodium Species

SpeciesCommon NameSeverityFever PatternGeographic Distribution
P. falciparumMalignant malariaMost severe; causes cerebral malaria; can be fatalIrregular or continuousPredominant in Africa; most deadly globally
P. vivaxBenign tertianLess severe but can relapse (dormant liver forms — hypnozoites)Every 48 hours (tertian)Most widespread globally; dominant in India and Asia
P. malariaeQuartan malariaMild; can persist for decadesEvery 72 hours (quartan)Tropical regions worldwide
P. ovaleOvale tertianMild; can relapseEvery 48 hoursWest Africa primarily
P. knowlesiKnowlesi malariaCan be severe; zoonotic (from macaque monkeys)Daily (quotidian)Southeast Asia (Malaysia, Borneo)

Prelims Tip: There are 5 Plasmodium species that cause malaria in humans. P. falciparum is the deadliest; P. vivax is the most widespread outside Africa and is the dominant species in India. The vector is always the female Anopheles mosquito.


Vector-Borne Diseases — Quick Reference

DiseaseVectorPathogen
MalariaFemale Anopheles mosquitoPlasmodium spp.
DengueAedes aegypti mosquitoDengue virus
ChikungunyaAedes aegypti/albopictus mosquitoChikungunya virus
ZikaAedes aegypti mosquitoZika virus
Japanese EncephalitisCulex mosquitoJE virus
Kala-azarSandfly (Phlebotomus)Leishmania donovani
Sleeping SicknessTsetse fly (Glossina)Trypanosoma brucei
Plague (Bubonic)Rat flea (Xenopsylla cheopis)Yersinia pestis
TyphusBody louse / fleaRickettsia spp.
Filariasis (Elephantiasis)Culex mosquitoWuchereria bancrofti

Prelims Tip: Aedes aegypti transmits dengue, chikungunya, Zika, and yellow fever. Anopheles transmits only malaria. Culex transmits Japanese Encephalitis and filariasis.


Part IV — Non-Communicable Diseases (NCDs)

NCDs account for approximately 66% of all deaths in India (WHO estimate). The four major NCDs are cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes.

Major NCDs

DiseaseKey Facts
Cardiovascular Diseases (CVDs)Leading cause of death globally; includes heart attacks and strokes; risk factors: hypertension, high cholesterol, smoking, obesity, physical inactivity, diabetes
CancerUncontrolled cell division; major types in India: oral, lung, breast, cervical; risk factors: tobacco, alcohol, radiation, genetic mutations, viral infections (HPV for cervical cancer)
Diabetes MellitusType 1: autoimmune destruction of insulin-producing beta cells in pancreas (juvenile onset); Type 2: insulin resistance (adult onset, linked to obesity/lifestyle) — accounts for ~95% of cases; India has the second-highest number of diabetics globally
Chronic Obstructive Pulmonary Disease (COPD)Progressive lung disease causing obstructed airflow; includes chronic bronchitis and emphysema; risk factors: smoking, air pollution, biomass fuel exposure

Part V — Vaccines and Immunisation

Types of Vaccines

Vaccine TypeMechanismExamples
Live AttenuatedContains weakened form of the pathogen; triggers strong, long-lasting immunityBCG (TB), OPV (Polio), MMR (Measles, Mumps, Rubella), Yellow Fever
Inactivated (Killed)Contains killed pathogen; weaker immune response, may need boostersIPV (Polio — Salk), Rabies vaccine, Hepatitis A vaccine, Covaxin (COVID-19)
ToxoidContains inactivated toxin (not the pathogen itself); targets bacterial toxinsDPT vaccine — tetanus and diphtheria components are toxoids
Subunit / RecombinantContains only specific proteins or antigens from the pathogenHepatitis B vaccine (HBsAg protein), HPV vaccine, Corbevax (COVID-19)
mRNADelivers mRNA encoding a pathogen protein; cells produce the protein, triggering immunity; mRNA is broken down by the body after usePfizer-BioNTech (Comirnaty), Moderna (Spikevax) — both for COVID-19
Viral VectorUses a harmless virus to deliver pathogen genetic material into cellsAstraZeneca/Covishield (COVID-19), Sputnik V, Johnson & Johnson

Prelims Tip: mRNA vaccines do NOT alter human DNA. The mRNA provides temporary instructions to cells to produce a protein (spike protein in COVID-19), which the immune system then recognises and attacks. The mRNA is broken down and eliminated by the body.

India's Universal Immunisation Programme (UIP)

India's UIP, launched in 1985, is one of the largest immunisation programmes in the world.

AspectDetails
Launched1985 (expanded from the EPI — Expanded Programme on Immunisation started in 1978)
Coverage TargetAll pregnant women and 85% of infants against vaccine-preventable diseases
Original 6 Antigens (1985)BCG (tuberculosis), DPT (diphtheria, pertussis, tetanus), OPV (polio), Measles, and Tetanus Toxoid for pregnant women
Current CoverageCovers 12 vaccine-preventable diseases including Hepatitis B (2007-08), Pentavalent (2014), Measles-Rubella (2017), Rotavirus, PCV (Pneumococcal), JE (in endemic districts), IPV
Mission IndradhanushLaunched December 2014 to achieve full immunisation coverage for children and pregnant women in low-coverage districts; Intensified Mission Indradhanush (IMI) launched 2017

Part VI — Disease Eradication and Elimination

Key Milestones

DiseaseStatusKey Date/Details
SmallpoxEradicated globallyLast naturally occurring case: 26 October 1977 (Ali Maow Maalin, Somalia); WHO certified global eradication on 8 May 1980; the only human disease ever eradicated
PolioEliminated in IndiaIndia's last wild poliovirus case: 13 January 2011 (Howrah, West Bengal); WHO South-East Asia Region (including India) certified polio-free on 27 March 2014; global eradication ongoing — endemic in Afghanistan and Pakistan
Guinea Worm DiseaseNearly eradicated globallyCases reduced from 3.5 million (1986) to fewer than 15 (2023); led by the Carter Center
Tuberculosis (TB)India's 2025 elimination target missed (ahead of global SDG target of 2030); India now realigns efforts toward the global 2030 elimination targetIndia carries the world's highest TB burden; NTEP (National TB Elimination Programme) driving efforts; Ni-kshay digital platform
MalariaElimination target in IndiaNational Framework for Malaria Elimination (2016-2030); India aims for malaria-free status by 2030
LeprosyEliminated as public health problem in India (2005)Prevalence reduced to <1 per 10,000 population at national level; however, some states still have higher prevalence
YawsIndia declared yaws-freeIndia declared yaws-free in May 2016 by WHO

Prelims Tip: Smallpox is the ONLY human disease eradicated. Polio is eliminated from India (no cases since 2011) but not eradicated globally. Rinderpest (a cattle disease) was declared eradicated in 2011 — the only animal disease eradicated.


Part VII — Major Epidemics and Pandemics

Pandemic/EpidemicPeriodPathogenEstimated DeathsKey Facts
Black Death1346-1353Yersinia pestis (Bubonic Plague)75-200 millionSpread via rat fleas along trade routes; killed 30-60% of Europe's population
Spanish Flu1918-1920H1N1 Influenza virus50-100 million globally; ~18 million in IndiaInfected ~500 million people (~1/3 of world population); India was among the worst-hit countries
HIV/AIDS Pandemic1981-presentHIV~40 million deaths (cumulative)First identified in 1981; no cure but ART controls the virus; UNAIDS coordinates global response
COVID-192019-presentSARS-CoV-2~7 million confirmed (likely significantly higher)Declared pandemic by WHO on 11 March 2020; led to development of mRNA vaccines within a year; India faced severe Delta wave (April-June 2021)
Ebola (West Africa)2014-2016Zaire ebolavirus~11,300Largest Ebola outbreak; primarily Guinea, Liberia, Sierra Leone

India's Public Health Response Mechanisms

MechanismDetails
Integrated Disease Surveillance Programme (IDSP)India's disease surveillance network; renamed Integrated Health Information Platform (IHIP) in 2021; digitised, real-time disease outbreak monitoring
National Centre for Disease Control (NCDC)Nodal body for disease surveillance and outbreak investigation; headquartered in Delhi
WHO International Health Regulations (IHR)International framework requiring countries to report public health emergencies of international concern (PHEIC) to WHO; India is a signatory
One Health ApproachRecognises the interconnection between human, animal, and environmental health; critical for addressing zoonotic diseases (diseases that jump from animals to humans — e.g., Nipah, COVID-19, Ebola)

Part VIII — Fungal and Helminthic Diseases

Common Fungal Diseases

DiseaseCausative OrganismAffected AreaTransmission
RingwormTrichophyton, MicrosporumSkin, scalp, nailsDirect contact; contaminated surfaces
Candidiasis (Thrush)Candida albicansMouth, throat, genitalsOpportunistic — occurs when immune system is weakened
AspergillosisAspergillus speciesLungsInhalation of fungal spores; risk in immunocompromised patients
Mucormycosis (Black Fungus)Mucor, RhizopusSinuses, brain, lungsInhalation of spores; surged during COVID-19 Delta wave (2021) in India, particularly in diabetic and steroid-treated patients

Common Helminthic (Worm) Diseases

DiseaseCausative OrganismTransmissionSymptoms
AscariasisAscaris lumbricoides (roundworm)Faecal-oral (contaminated soil/food)Abdominal pain, malnutrition, intestinal obstruction
Filariasis (Elephantiasis)Wuchereria bancroftiVector-borne — Culex mosquitoSwelling of limbs (lymphedema), lymphatic damage; India runs National Programme for Elimination of Lymphatic Filariasis (NPELF) with annual mass drug administration (albendazole + DEC) in endemic districts
Tapeworm InfectionTaenia solium (pork), T. saginata (beef)Undercooked contaminated meatAbdominal discomfort; cysticercosis if larvae invade tissues
Hookworm DiseaseAncylostoma duodenaleLarvae penetrate bare feet from contaminated soilIron-deficiency anaemia, fatigue

Frequently Asked Prelims Questions — Pattern

Question PatternAnswer
Which Plasmodium species is most fatal?P. falciparum
Vector for malaria?Female Anopheles mosquito
Vector for dengue?Aedes aegypti mosquito
Vector for kala-azar?Sandfly (Phlebotomus)
Only human disease eradicated?Smallpox (certified 1980)
India polio-free since?Last case January 2011; WHO certified 27 March 2014
What does BCG vaccine prevent?Tuberculosis
What does DPT vaccine prevent?Diphtheria, Pertussis, Tetanus
UIP launched in?1985
Hepatitis types transmitted through water?Hepatitis A and E
Hepatitis types transmitted through blood?Hepatitis B, C, D
What is a zoonotic disease?Disease transmitted from animals to humans
What is herd immunity?Indirect protection when sufficient population is immune
mRNA vaccines — do they alter DNA?No — mRNA is temporary; broken down after use

Recent Developments (2024–2026)

India's Disease Milestones — WHO 2024 Annual Report

WHO's 2024 India Country Report documented landmark disease elimination milestones: India eliminated trachoma as a public health problem, near-eliminated kala-azar (visceral leishmaniasis) with cases below the elimination threshold in most endemic districts, achieved an 80% decline in malaria cases vs 2015 (from ~1.1 crore to ~22 lakh), and maintained polio-free status. India's National TB Elimination Programme progressed toward the 2025 End-TB targets, with TB incidence declining though remaining above the global average.

UPSC angle: India's disease elimination milestones from WHO 2024 are directly verifiable and highly examinable — cover trachoma, kala-azar, malaria, and TB status for Prelims fact questions.

TB Elimination Progress — 2025 Target Missed, 2030 Realignment (March 2025 Update)

India's 2025 TB elimination target (set to achieve End-TB goals 5 years ahead of the global SDG 2030 target) was not met, but significant progress was recorded. On World TB Day (March 24, 2025), the Ministry of Health reported: TB incidence declined by 17.7% (from 237 cases per 1 lakh population in 2015 to 195 in 2023); TB deaths fell from 28 to 22 per 1 lakh population over the same period; treatment success rate reached 87.6% in 2023 (up from 84% in 2021). India's missing cases (undetected/unreported TB) fell from 15 lakh in 2015 to 2.5 lakh in 2023 — an 83% reduction. The government launched a 100-Day TB Elimination Campaign in 2025 in high-burden districts. Nikshay Poshan Yojana (NPY) — providing ₹500/month nutritional support to TB patients — had disbursed ₹2,781 crore to ~1 crore beneficiaries cumulatively by 2023. India now realigns toward the global 2030 TB elimination target, with the improved Bedaquiline-based regimen and mBPaL (Bedaquiline-Pretomanid-Linezolid) as newer drug-resistant TB treatment options.

UPSC angle: Prelims — TB incidence 195/lakh (2023); 17.7% decline; 2025 target missed; 2030 realignment; Nikshay Poshan Yojana ₹500/month. Mains GS3 — India's TB burden and NTEP; public health approach to elimination; nutrition-TB linkage; drug-resistant TB challenge.


Mpox (Monkeypox) — India's Preparedness (2024)

The 2024 global mpox outbreak (WHO declared a Public Health Emergency of International Concern — PHEIC — in August 2024) prompted India's ICMR and NCDC to strengthen surveillance for novel mpox clade Ib strains. India did not report a significant outbreak, but the event reinforced the One Health surveillance framework connecting animal-to-human disease transmission. This echoes lessons from COVID-19 and Nipah preparedness.

UPSC angle: Mpox 2024 PHEIC tests knowledge of WHO emergency declarations, zoonotic disease mechanisms, and India's epidemic preparedness infrastructure.


Key Terms for Quick Revision

TermMeaning
PathogenA microorganism that causes disease (bacteria, virus, fungus, protozoan)
VectorAn organism (usually insect) that transmits a pathogen from one host to another
ZoonosisDisease transmitted from animals to humans (e.g., rabies, Nipah, COVID-19)
PandemicWorldwide spread of a new disease affecting large numbers across multiple countries
EpidemicSudden increase in disease cases above the expected level in a community
EndemicConstant baseline presence of a disease in a geographic area (e.g., malaria in India)
Herd ImmunityWhen a sufficient proportion of a population is immune, providing indirect protection to those not immune
DOTSDirectly Observed Treatment, Short-course — WHO-recommended strategy for TB treatment
ARTAntiretroviral Therapy — treatment regimen for HIV/AIDS
PHEICPublic Health Emergency of International Concern — WHO's highest alert level
mRNA VaccineVaccine using messenger RNA to instruct cells to produce a pathogen protein, triggering immunity
Live Attenuated VaccineVaccine containing a weakened (but living) form of the pathogen
HypnozoiteDormant form of P. vivax and P. ovale in the liver, causing malaria relapses
Antigenic DriftGradual mutations in virus genes causing small changes in surface proteins; reason flu vaccines are updated annually
Antigenic ShiftMajor genetic reassortment in viruses (e.g., influenza) producing a new subtype; can cause pandemics
Case Fatality Rate (CFR)Proportion of people diagnosed with a disease who die from it
Incubation PeriodTime between infection and appearance of first symptoms
QuarantineIsolation of healthy individuals who may have been exposed to a disease
SeroprevalenceProportion of a population with antibodies against a specific pathogen

Sources: WHO (who.int); CDC (cdc.gov); National Health Mission (nhm.gov.in); Britannica; Wikipedia.